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services
At Arcoscreen we are committed to developing solutions that simplify and streamline the identification of promising GPCR drugs, which we believe will bring to the market new life saving drugs.
We also produce for you customize stable cells line expressing specific GPCR receptors.
Arcoflow Gα activation:
Drug molecular mode of action identification in primary cells
We are able to determine which Gα subunit is involved in the activation of endogenous GPCRs expressed in primary cells.
What we provide
Molecular mode of action against any GPCR in mammalian cells.
EC50s and IC50s values.
384 Microfluidics well plate format.
Output
Determination of the Gα subunits involved in the activation of endogenous receptors expressed in stable cell lines or primary cells.
Arcoflow GTPγS activation:
GPCR activation in primary cells
Validate new targets early to rapidly move your best drug candidates into clinical trials. ArcoFlow GTPγS is simple, fast, and cost-effective alternative to in-house profiling and screening is ideal for any size compound collection.
What we provide
GPCR activation in any mammalian cell.
EC50s and IC50s values.
384 Microfluidics well plate format.
Output
Determination of the activation dose-response curve of any GPCR receptor in mammalian cells.
Ready to use or customize GPCR stable cell lines
The ArcoScreen team has 2 decades of experience generating GPCR expressing stable cell lines. ArcoScreen offers a complete package for stable cell line development utilizing CHO-TRex or HEK-TRex cells. The time consuming and strenuous process will be handled by our team of experts to develop the inducible stable cell lines you need for protein production and cell-based assays. Further assay development and characterization can also be done at our R&D facility, including but not limited to flow cytometry, or immunohistochemistry.
List of GPCR stable cell lines available
ArcoScreen has a library of inducible cell lines for 85 human GPCRs in HEK TRex or CHO TRex cells.
Custom GPCR stable cell lines production
ArcoScreen offers stable a cell line development service for a wide variety of GPCRs.
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