Arcoflow platform
Our solution is composed of a novel biological assay enabling the molecular mode of action identification directly in any primary cell, embedded in a microfluidic device.
Our microfluidic technology:
accelerates the assay (20 min),
decrease the amount of reagents needed (2 uL volume chamber),
standardizes the entire assay (integration of the microfluidics in standard 384 well plate)
Features
-
Primary cells
Our new biological assay allows us to test any mammalian cell and preserves the native environment of the GPCR
-
G protein determination
We determine which G protein is involved in the GPCR activation (i.e. molecular mode of action)
-
Microfluidic well plate
Our assay is embeded in custom microfluidic 384 well plate
-
Fluorescence
Our simple fluorescent read out allows us to directly detect the GPCR activation
Workflow
-
Compounds to be tested & primary cells
-
Arcoflow well plate & reagents
-
Mode of action & identification of promising compounds
-
Promising compounds moved to preclinical
Read next